Y — Yellow Fever Virus
Yellow fever virus (YFV) is a flavivirus transmitted by Aedes mosquitoes in urban cycles and Haemagogus species in sylvatic cycles. After infection, the virus spreads to lymph nodes and then via viremia to visceral organs, particularly the liver.
YFV demonstrates marked hepatotropism, infecting hepatocytes and causing midzonal necrosis with characteristic eosinophilic apoptotic bodies (Councilman bodies). Severe disease involves jaundice, coagulopathy, haemorrhage, and shock — the “toxic phase.”
NS proteins antagonize interferon responses, enabling early viral replication. Severe disease correlates with high viral load and dysregulated immune activation.
The live-attenuated 17D vaccine is one of the most successful vaccines ever developed, inducing durable neutralizing antibody responses. Rare adverse events include viscerotropic and neurotropic vaccine-associated disease.
Research examines determinants of viscerotropism, immune correlates of protection, and mechanisms underlying rare vaccine complications.
Yellow fever virus (YFV) is a flavivirus transmitted by Aedes mosquitoes in urban cycles and Haemagogus species in sylvatic cycles. After infection, the virus spreads to lymph nodes and then via viremia to visceral organs, particularly the liver.
YFV demonstrates marked hepatotropism, infecting hepatocytes and causing midzonal necrosis with characteristic eosinophilic apoptotic bodies (Councilman bodies). Severe disease involves jaundice, coagulopathy, haemorrhage, and shock — the “toxic phase.”
NS proteins antagonize interferon responses, enabling early viral replication. Severe disease correlates with high viral load and dysregulated immune activation.
The live-attenuated 17D vaccine is one of the most successful vaccines ever developed, inducing durable neutralizing antibody responses. Rare adverse events include viscerotropic and neurotropic vaccine-associated disease.
Research examines determinants of viscerotropism, immune correlates of protection, and mechanisms underlying rare vaccine complications.